Electrical and Mechanical Strategies to Enable Cardiac Repair and Regeneration PROJECT TITLE :Electrical and Mechanical Strategies to Enable Cardiac Repair and RegenerationABSTRACT:Inadequate replacement of lost ventricular myocardium from myocardial infarction results in heart failure. Investigating the regenerative capacity of mammalian hearts represents an emerging direction for tissue engineering and cell-based therapy. Recent advances in stem cells hold promise to restore cardiac functions. However, embryonic or induced pluripotent stem cell-derived cardiomyocytes lack practical phenotypes of the native myocardium, and transplanted tissues aren't fully integrated for synchronized electrical and mechanical coupling with the host. During this context, this review highlights the mechanical and electrical ways to push cardiomyocyte maturation and integration, and to assess the purposeful phenotypes of regenerating myocardium. Simultaneous microelectrocardiogram and high-frequency ultrasound techniques will also be introduced to assess electrical and mechanical coupling for little animal models of heart regeneration. Did you like this research project? To get this research project Guidelines, Training and Code... Click Here facebook twitter google+ linkedin stumble pinterest Review of Robotic Technology for Stereotactic Neurosurgery Architecture Haiku: A Case Study in Lean Documentation [The Pragmatic Architect]
