Control of Iron Oxide Nanoparticle Clustering Using Dual Solvent Exchange


Superparamagnetic iron oxide nanoparticles (SPIOs) have considerable promise for magnetic resonance imaging, drug/gene delivery, and hyperthermia applications. It has been shown recently that self-assembly of SPIOs into large superstructures can have a vital impact on their magnetic properties and functionality. In this work, we have a tendency to developed a novel methodology for controlling the clustering of SPIOs with 2 completely different core sizes (eight and 15 nm) by varying the number of amphiphilic coating molecules used throughout the dual solvent exchange coating method. We have a tendency to show that hydrodynamic size and T2 relaxivity will be increased using this approach, whereas the precise absorption rate (SAR) is decreased. These results demonstrate a brand new, easy method for triggering the self-assembly of SPIO clusters using commercially obtainable and biocompatible phospholipid-poly(ethylene glycol) (PEG) conjugates.

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