PROJECT TITLE :

Integrated dopaminergic neuronal model with reduced intracellular processes and inhibitory autoreceptors

ABSTRACT:

Dopamine (DA) is a crucial neurotransmitter for multiple brain functions, and dysfunctions of the dopaminergic system are implicated in neurological and neuropsychiatric disorders. Although the dopaminergic system has been studied at multiple levels, an integrated and economical computational model that bridges from molecular to neuronal circuit level continues to be lacking. During this study, the authors aim to develop a realistic nonetheless economical computational model of a dopaminergic pre-synaptic terminal. They initial systematically perturb the variables/substrates of a longtime computational model of DA synthesis, unleash and uptake, and based on their relative dynamical timescales and steady-state changes, approximate and cut back the model into two versions: one for simulating hourly timescale, and another for millisecond timescale. They show that the original and reduced models exhibit rather similar steady and perturbed states, whereas the reduced models are more computationally efficient and illuminate the underlying key mechanisms. They then incorporate the reduced quick model into a spiking neuronal model that may realistically simulate the spiking behaviour of dopaminergic neurons. In addition, they successfully embody autoreceptor-mediated inhibitory current explicitly within the neuronal model. This integrated computational model provides the first step toward an economical computational platform for realistic multiscale simulation of dopaminergic systems in in silico neuropharmacology.


Did you like this research project?

To get this research project Guidelines, Training and Code... Click Here


PROJECT TITLE : IPFS and Blockchain based Reliability and availability improvement for integrated Rivers’ streamflow data ABSTRACT: The collection of data on streamflow using a variety of methods and the dissemination of
PROJECT TITLE : STAR-RIS Integrated Nonorthogonal Multiple Access and Over-the-Air Federated Learning Framework, Analysis, and Optimization ABSTRACT: In this paper, nonorthogonal multiple access (NOMA) and over-the-air federated
PROJECT TITLE : Space-Air-Ground Integrated Multi-domain Network Resource Orchestration based on Virtual Network Architecture a DRL Method ABSTRACT: Due to deployment, coverage, and capacity issues, traditional ground wireless
PROJECT TITLE : High Frequency PCB Winding Transformer with Integrated Inductors for a Bi-directional Resonant Converter ABSTRACT: Unrelenting progress is being made toward high-power density, high-efficiency power converters.
PROJECT TITLE : Dynamic Performance of Solar PV Integrated UPQC-P for Critical Loads ABSTRACT: These results demonstrate the dynamic performance of an integrated UPQC-P array for critical loads, including a solar photovoltaic

Ready to Complete Your Academic MTech Project Work In Affordable Price ?

Project Enquiry