PROJECT TITLE :

Respiratory tract toxicity of titanium dioxide nanoparticles and multi-walled carbon nanotubes on mice after intranasal exposure

ABSTRACT:

Titanium dioxide nanoparticles (TiO2-NPs) and multi-walled carbon nanotubes (MWCNTs) are employed in various industrial and household products. Because of their little size they'll be ready to penetrate into the body and interfere with cell perform and biological structure, which raises serious considerations regarding the attainable adverse health effects on folks from inhalation exposure to TiO2-NPs and MWCNTs. To judge the toxicological effects of TiO2-NPs and MWCNTs on the respiratory system, intranasal exposure of TiO2-NPs and MWCNTs in mice was performed. The discharge of lactate dehydrogenase (LDH), total protein content, and professional-inflammatory cytokines (tumour necrosis issue-alpha and interleukin-vi) into the bronchoalveolar lavage fluid of mice was measured at twenty four h post-intranasal instillation. The ICR (Institute for Cancer Research) mouse strain was used as a model. A significant induction of LDH was found in ICR mice treated with TiO2-NPs and MWCNTs at a degree of 500 μg (kg bw)-one. However, a better degree of induction was detected in mice treated with TiO2-NPs than those that were treated with MWCNTs. In contrast, MWCNTs at the identical concentration had additional impact on the discharge of protein content and pro-inflammatory cytokines. The ends up in this work additionally suggest that the toxic effects of each TiO2-NPs and MWCNTs on the respiratory tract depend on their concentration. The next concentration of each particles largely induced the assembly of inflammatory signals.


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