PROJECT TITLE :

Kinetic Modeling of Hyperpolarized Carbon-13 Pyruvate Metabolism in the Human Brain

ABSTRACT:

Modeling pyruvate to lactate conversion in vivo is essential to understanding abnormal cancer metabolism that exhibits Warburg effect changes. The ability to identify changes in metabolic flux non-invasively could be useful for early diagnosis and better treatment response monitoring. Hyperpolarized [1- 13 C] pyruvate was given intravenously into 10 patients with brain tumours in order to determine the rate of lactate (k PL) and bicarbonate (k PB) conversion by echo-planar imaging in this clinical research endeavour. Our goal was to find novel ways to cover the entire brain in k PL and k PB maps. Data-driven analysis was used to pick the best model for fitting our data and to calculate an appropriate goodness-of-fit value for the model. According to the results of the statistical analysis, the best agreement with the data was found in an input-less model. When voxels were chosen based on post-fitting error criteria, greater precision and coverage were obtained than when signal-to-noise cutoffs were just used.


Did you like this research project?

To get this research project Guidelines, Training and Code... Click Here


PROJECT TITLE :Modeling, Limits and Baseline of Voltage Interharmonics Generation in Andean Wind FarmsABSTRACT:The subsequent study focuses on the analysis of voltage interharmonics based mostly on power quality experimental information
PROJECT TITLE :Modeling, Measuring, and Compensating Color Weak VisionABSTRACT:We tend to use strategies from Riemann geometry to investigate transformations between the colour spaces of color-normal and color-weak observers.
PROJECT TITLE :Modeling, Analysis, and Scheduling of Cluster Tools With Two Independent ArmsABSTRACT:Twin-armed cluster tools for semiconductor manufacturing sometimes have had two arms fixed in opposite directions. Recently,
PROJECT TITLE :Modeling, Analysis, and Detection of Internal Winding Faults in Power TransformersABSTRACT:The winding interturn fault is critical in power transformers since its result is not simply comprehensible at lower magnitude
PROJECT TITLE :Modeling, Autopilot Design, and Field Tuning of a UAV With Minimum Control SurfacesABSTRACT:Whereas having the benefit of mechanical simplicity, model-scale unmanned aerial vehicles with solely two elevon management

Ready to Complete Your Academic MTech Project Work In Affordable Price ?

Project Enquiry