A Hybrid Semi-Digital Transimpedance Amplifier With Noise Cancellation Technique for Nanopore-Based DNA Sequencing


Over the past two decades, nanopores are a promising technology for next generation deoxyribonucleic acid (DNA) sequencing. Here, we tend to present a hybrid semi-digital transimpedance amplifier (HSD-TIA) to sense the minute current signatures introduced by single-stranded DNA (ssDNA) translocating through a nanopore, whereas discharging the baseline current employing a semi-digital feedback loop. The amplifier achieves fast settling by adaptively tuning a DC compensation current when a step input is detected. A noise cancellation technique reduces the full input-referred current noise caused by the parasitic input capacitance. Measurement results show the performance of the amplifier with thirty one.half-dozen M$Omega$ mid-band gain, 950 kHz bandwidth, and 8.5 fA/$surd$Hz input-referred current noise, a $a pair oftimes$ noise reduction thanks to the noise cancellation technique. The settling response is demonstrated by observing the insertion of a protein nanopore during a lipid bilayer. Using the nanopore, the HSD-TIA was in a position to live ssDNA translocation events.

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