A Simple Low-Dose X-Ray CT Simulation From High-Dose Scan


Low-dose X-ray computed tomography (CT) simulation from a high-dose scan is needed in optimizing radiation dose to patients. During this paper, we tend to propose a simple low-dose CT simulation strategy in the sinogram domain using the raw data from high-dose scan. Specially, a relationship between the incident fluxes of low- and high-dose scans is 1st determined according to the repeated projection measurements and analysis. Second, the incident flux level of the simulated low-dose scan is generated by properly scaling the incident flux level of the high-dose scan via the determined relationship in the primary step. Third, the low-dose CT transmission information by energy integrating detection is simulated by adding a statistically freelance Poisson noise distribution plus a statistically independent Gaussian noise distribution. Finally, a filtered back-projection (FBP) algorithm is implemented to reconstruct the resultant low-dose CT images. The current low-dose simulation strategy is verified on the simulations and real scans by comparing it with the existing low-dose CT simulation tool. Experimental results demonstrated that the present low-dose CT simulation strategy will generate correct low-dose CT sinogram information from high-dose scans in terms of qualitative and quantitative measurements.

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