Inferring Time-Delayed Causal Gene Network Using Time-Series Expression Data


Inferring gene regulatory network (GRN) from the microarray expression information is an important problem in Bioinformatics, as a result of knowing the GRN is a vital initial step in understanding the inner workings of the cell and therefore the related diseases. Time delays exist within the regulatory effects from one gene to a different because of the time required for transcription, translation, and to accumulate a sufficient variety of required proteins. Conjointly, it's known that the delays are important for oscillatory phenomenon. Therefore, it is crucial to develop a causal gene network model, preferably as a operate of your time. In this paper, we tend to propose an algorithm CLINDE to infer causal directed links in GRN with time delays and regulatory effects within the links from time-series microarray gene expression knowledge. It's one in every of the foremost comprehensive in terms of features compared to the state-of-the-art discrete gene network models. We tend to have tested CLINDE on synthetic information, the in vivo IRMA (On and Off) datasets and also the [1] yeast expression information validated using KEGG pathways. Results show that CLINDE will effectively recover the links, the time delays and also the regulatory effects in the synthetic data, and outperforms different algorithms within the IRMA in vivo datasets.

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