Intestinal Manometry Force Sensor for Robotic Capsule Endoscopy: An Acute, Multipatient In vivo Animal and Human Study


Goal: Development of a new medical device class generally termed robotic capsule endoscopes (RCE) is currently being pursued by multiple research groups. These maneuverable devices can allow minimally invasive diagnosis and treatment of intestinal pathologies. Whereas the intraluminal pressures connected to the migrating motor advanced (MMC) are well understood, no previous study has measured the active contact forces exerted by the human tiny bowel wall on a solid, or near solid bolus like an RCE. Understanding and quantifying the active contact force are critical for the advancement of RCE technology. Ways: In this study, the authors develop a completely unique manometric contact force sensor for human studies and validate the feasibility of the look, sterilization methodology, and minimally invasive surgery in a multianimal study, followed by a multihuman study. Results: Four porcine tests of the sensor were conducted. The mean porcine myenteric contact force measured using the new sensor is one.20 ± 0.08 N·cm−one. The mean myenteric contact force recorded for all five human test subjects is 0.eighteen ± 0.33 N·cm−one. Conclusion: This study demonstrates the feasibility of operating an MMC force sensor during a live human with a minimally invasive surgical technique and presents force data necessary for RCE style. Significance: This study represents the primary known myenteric contact force measurements on a solid bolus in the human little intestine.

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