Molecular dynamic simulation of Ca2+-ATPase interacting with lipid bilayer membrane


In biomedical and drug delivery treatments, protein Ca2+-ATPase in the lipid bilayer (plasma) membrane plays a key role by reducing multidrug resistance of the cancerous cells. The lipid bilayer membrane and the protein Ca2+-ATPase were simulated by utilising the Gromacs software and by applying the all-atom/united atom and coarse-grained models. The initial structure of Ca2+-ATPase was derived from X-ray diffraction and electron microscopy patterns and was placed during a simulated bilayer membrane of dipalmitoylphosphatidylcholine. The conformational changes were investigated by evaluating the basis mean sq. deviation, root mean sq. fluctuation, order parameter, diffusion coefficients, partial density, thickness and space per lipid.

Did you like this research project?

To get this research project Guidelines, Training and Code... Click Here

PROJECT TITLE :Dynamic, Fine-Grained Data Plane Monitoring With Monocle - 2018ABSTRACT:Ensuring network reliability is important for satisfying service-level objectives. However, diagnosing network anomalies during a timely fashion
PROJECT TITLE :Molecular MIMO: From Theory to PrototypeABSTRACT:In diffusion-based molecular communication, information transport is ruled by diffusion through a fluid medium. The achievable information rates for these channels
PROJECT TITLE :Low-Complexity Noncoherent Signal Detection for Nanoscale Molecular CommunicationsABSTRACT:Nanoscale molecular communication could be a viable means of exchanging info between nanomachines. In this investigation,
PROJECT TITLE :Modelling, simulation, and verification for detailed short-circuit analysis of a 1 × 25 kV railway traction systemABSTRACT:This study presents a modelling and simulation method for the analysis of short-circuits
PROJECT TITLE :Numerical simulation on molecular displacement and DC breakdown of LDPEABSTRACT:It is generally known that the dc breakdown strength of low density polyethylene (LDPE) decreases with because the thickness and temperature

Ready to Complete Your Academic MTech Project Work In Affordable Price ?

Project Enquiry