Modeling the Dynamic Processing of the Presynaptic Terminals for Intrabody Nanonetworks

PROJECT TITLE :

Modeling the Dynamic Processing of the Presynaptic Terminals for Intrabody Nanonetworks

ABSTRACT:

Experimental evidences show that: 1) the discharge sites from a single axon have variable unleash chances, even when the axon contacts the same postsynaptic neuron; two) this variability in the release chance implies a compartmentalization at the extent of the presynaptic terminals of the neuronal processing; 3) the specificity of the presynaptic terminal processing is driven by and reflects the complicated biophysical mechanisms activated at the axon terminals when a spike is fired in response to a stimulus. Stemming from these experimental evidences, we propose a Communication engineering model for capturing the behavior of biological neurons. Specifically, by adopting a stochastic approach, the presynaptic terminals are modeled as a dynamic array of transmitters, where each transmitter models the processing specificity of a presynaptic terminal. In particular, we initial show that the distinctive and specific processing of a presynaptic terminal will be reconducted to the cascade of a frequency selector and an amplitude modulator. Then, we characterize the propagation of the presynaptic-filtered signal through the synaptic cleft, and we derive the delay together with the channel attenuation as a perform of the gap between the communicating neurons. Finally, the theoretical analysis is validated through numerical simulation.

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