PROJECT TITLE :

One-step method for the preparation of poly(methyl methacrylate) modified titanium-bioactive glass three-dimensional scaffolds for bone tissue engineering

ABSTRACT:

A unique 3-dimensional (3D) titanium (Ti)-doping meso-macroporous bioactive glasses (BGs)/poly(methyl methacrylate) (PMMA) composite was synthesised using PMMA and EO20PO70EO20 (P123) as the macroporous and mesoporous templates, respectively. Unlike the standard calcination technique, the acid steam technique was used to enhance the polycondensation of Ti-BGs, and then PMMA was partially extracted via chloroform to induce the macroporous structure. Simultaneously, the residual PMMA that remained within the wall enhanced the compressive strength to a pair of.4 MPa (0.3 MPa for pure BGs). It is a straightforward and green methodology to prepare the macro-mesoporous Ti-BGs/PMMA. The materials showed the 3D interconnected hierarchical structure (250 and 3.four nm), creating the quick inducing-hydroxyapatite growth and therefore the controlled drug unharness. Besides mentioned above, the good antimicrobial property and biocompatible of the scaffold additionally ensure it's further of clinical use. Herein, the fabricated materials are expected to own potential application on bone tissue regeneration.