My Account | Careers | Downloads | Blog

PROJECT TITLE :

Two-dimensional cantilever array with varying spring constants and tip radii for life-science applications

ABSTRACT:

A fabrication process for realising two-dimensional cantilever arrays for parallel force spectroscopy of biological samples is presented. The parallel optical atomic force microscopy readout system has been developed and presented elsewhere. The arrays are designed either for (i) force-indentation onto living cells to obtain stiffness mapping or (ii) cell adhesion experiments. Both experiments require very different spring constants and tip radii of curvature. The arrays are based on silicon nitride cantilevers with molded tips. The fabrication process includes an advanced molding process and a thermocompression bonding of two silicon wafers. V-groove structures along the cantilevers, which increase the area moment of inertia, were introduced in the cantilever design. This feature enables the fabrication of cantilevers with different spring constants but same footprint from one wafer. An analytical model and experimental results confirmed that the spring constant of the cantilever (200×50×0.45 μm) could be increased up to two decades (0.03×5×N/m) by changing the depth of the V-grooves. To realise the large tip radius required for cell adhesion experiments, an enlarging/rounding procedure has been applied to a truncated pyramidal tip mold. With this process, the authors obtained tips with a radius up to 4 μm.


Did you like this research project?

To get this research project Guidelines, Training and Code... Click Here

PROJECT TITLE : Short Text Topic Modeling Techniques, Applications, and Performance: A Survey ABSTRACT: The semantic understanding of short texts is required for a wide variety of real-world applications, so their analysis allows
PROJECT TITLE :On Two-Dimensional Hilbert Integral Equations, Generalized Minimum-Phase Signals, and Phase Retrieval - 2018ABSTRACT:One-dimensional (1-D) causal signals admit Hilbert integral relations between the important and
PROJECT TITLE :Dynamic Polarization Control of Two-Dimensional Integrated Phased ArraysABSTRACT:Simultaneous 2-dimensional (2-D) beam steering and dynamic polarization management (DPC) of the radiated electrical field in 2-D phased
PROJECT TITLE :Two-Dimensional Wavelet Analysis of Supraorbital Margins of the Human Skull for Characterizing Sexual DimorphismABSTRACT:The accurate determination of the sex of human skeletal remains could be a crucial challenge
PROJECT TITLE :A Novel Two-Dimensional Sparse-Weight NLMS Filtering Scheme for Passive Bistatic RadarABSTRACT:In passive bistatic radars, weak target echoes may often be masked by direct path interference, multipath components,

Ready to Complete Your Academic MTech Project Work In Affordable Price ?

Project Enquiry