The “Fingerprint” of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging Approach PROJECT TITLE :The “Fingerprint” of Cancer Extends Beyond Solid Tumor Boundaries: Assessment With a Novel Ultrasound Imaging ApproachABSTRACT:Goal: Abnormalities of microvascular morphology have been associated with tumor angiogenesis for more than a decade, and are believed to be intimately related to each tumor malignancy and response to treatment. However, the study of those vascular changes in-vivo has been challenged due to the dearth of imaging approaches which will assess the microvasculature in three-D volumes noninvasively. Here, we tend to use contrast-enhanced “acoustic angiography” ultrasound imaging to watch and quantify heterogeneity in vascular morphology around solid tumors. Methods: Acoustic angiography, a recent advance in contrast-enhanced ultrasound imaging, generates high-resolution microvascular pictures unlike something attainable with customary ultrasound imaging techniques. Acoustic angiography images of a genetically engineered mouse breast cancer model were acquired to develop an image acquisition and processing routine that isolated radially expanding regions of a 3-D image from the tumor boundary to the edge of the imaging field for assessment of vascular morphology of tumor and surrounding vessels. Results: Quantitative analysis of vessel tortuosity for the tissue surrounding tumors three to seven mm in diameter revealed that tortuosity decreased during a region 6 to ten mm from the tumor boundary, but was still considerably elevated in comparison to control vasculature. Conclusion: Our analysis of angiogenesis-induced changes within the vasculature outside the tumor margin reveals that the extent of abnormal tortuosity extends considerably beyond the first tumor mass. Significance: Visualization of abnormal vascular tortuosity could build acoustic angiography a useful tool for early tumor detection based mostly on quantifying the vascular footprint of tiny tumors and a sensitive methodology for understanding changes within the vascular microenvironment throughout tumor progression. Did you like this research project? To get this research project Guidelines, Training and Code... Click Here facebook twitter google+ linkedin stumble pinterest Fusion of Quantitative Image and Genomic Biomarkers to Improve Prognosis Assessment of Early Stage Lung Cancer Patients Novel Bone-Anchored Vascular Access on the Mastoid for Hemodialysis: Concept and Preclinical Trials