Vials: Visualizing Alternative Splicing of Genes

PROJECT TITLE :

Vials: Visualizing Alternative Splicing of Genes

ABSTRACT:

Different splicing is a method by which the identical DNA sequence is used to assemble totally different proteins, called protein isoforms. Different splicing works by selectively omitting some of the coding regions (exons) sometimes associated with a gene. Detection of different splicing is difficult and uses a mixture of advanced data acquisition ways and statistical inference. Information regarding the abundance of isoforms is important for understanding each normal processes and diseases and to eventually improve treatment through targeted therapies. The data, but, is advanced and current visualizations for isoforms are neither perceptually efficient nor scalable. To remedy this, we developed Vials, a novel visual analysis tool that enables analysts to explore the various datasets that scientists use to form judgments regarding isoforms: the abundance of reads related to the coding regions of the gene, evidence for junctions, i.e., edges connecting the coding regions, and predictions of isoform frequencies. Vials is scalable because it permits for the simultaneous analysis of the many samples in multiple groups. Our tool thus permits consultants to (a) establish patterns of isoform abundance in teams of samples and (b) evaluate the standard of the info. We have a tendency to demonstrate the price of our tool in case studies using publicly on the market datasets.

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