Improvement of Silicon Nanotweezers Sensitivity for Mechanical Characterization of Biomolecules Using Closed-Loop Control


During this paper, we show that closed-loop control will be advantageously used for the characterization of mechanical properties of biomolecules using silicon nanotweezers (SNT). SNT have already been utilized in open-loop mode for the characterization of mechanical properties of DNA molecules. Up to now, such an approach allows the detection of stiffness variations admire about fifteen DNA molecules. Here, it is shown that this resolution is inversely proportional to the resonance frequency of the entire system which real-time feedback control with state observer will drastically improve the performances of the tweezers used as biosensors. Such improvement is experimentally validated in the case of the manipulation of fibronectin molecules. The results are promising for the accurate characterization of biopolymers like DNA molecules.

Did you like this research project?

To get this research project Guidelines, Training and Code... Click Here

PROJECT TITLE :Operating Frequency Improvement On FPGA Implementation Of A Pipeline Large-FFT Processor - 2017ABSTRACT:In this paper, circuit complexity reduction in FPGA implementation of enormous N-point Radix-22 FFT with single-path
PROJECT TITLE :Improvement Of Bm3d Algorithm Based On Wavelet And Directed Diffusion - 2017ABSTRACT:Block-matching and 3D filtering (BM3D) has shown nice power for image denoising. By decomposing the BM3D restored image into three
PROJECT TITLE :Wide-Load-Range Efficiency Improvement for High-Frequency SiC-Based Boost Converter with Hybrid Discontinuous Current Mode - 2017ABSTRACT:This paper proposes a hybrid current mode between triangular current mode
PROJECT TITLE :Implementation of Echo-State Network Based Control for Power Quality Improvement - 2017ABSTRACT:This paper proposes a replacement control algorithm for mitigation of power quality issues at the distribution level.
PROJECT TITLE :Hybrid Energy Storage System Micro Grids Integration For Power Quality Improvement Using Four Leg Three Level NPC Inverter and Second Order Sliding Mode Control - 2017ABSTRACT:Rising demand for distributed generation

Ready to Complete Your Academic MTech Project Work In Affordable Price ?

Project Enquiry