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Reliability-Driven Chip-Level Design for High-Frequency Digital Microfluidic Biochips

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PROJECT TITLE :

Reliability-Driven Chip-Level Design for High-Frequency Digital Microfluidic Biochips

ABSTRACT:

Electrowetting-on-dielectric (EWOD) chips have emerged as popular actuators for droplet-based digital microfluidic biochips. The chip-level style of EWOD chips allows for the combination electrode addressing and wire routing, thus serving to deal with the increasing complexity of biochemical assays. Furthermore, high-frequency EWODs additionally facilitate finishing time-sensitive bioassays like incubation and emerging flash chemistry in specific time periods. But, the reliability of the EWOD chip is reduced by the contact angle modification reduction problem as a result of the repeated and frequent switching of electrodes. Therefore, the chip-level style of EWOD chips should consider reliability, electrode addressing, and also the wire routing drawback. This paper presents a graph-based mostly chip-level style algorithm. By setting the switching-time constraint, the amount of switching times will be limited to minimize the impact of the contact angle amendment reductions problem. Conjointly, a progressive addressing and routing approach is proposed to overcome the complicated wire routing problem. Experimental results show the proposed algorithm effectively minimizes the impact of the contact angle amendment reduction downside, so providing a reliable chip-level style with a possible wire routing answer with the desired range of pins.


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Reliability-Driven Chip-Level Design for High-Frequency Digital Microfluidic Biochips - 4.9 out of 5 based on 70 votes

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