PROJECT TITLE :
Integrin Targeted Gold Nanoparticles Potentiate Cancer Radiation Sensitivity: Synthesizing and modifying gold nanorods to target cancer cells.
RGD-PEG-GNRs facilitate specific targeting of integrin αvβhalf dozen that's selectively overexpressed in head and neck cancer, as well as HSC3. The GNRs were internalized to endosome and lysosomal vesicles through attaching to the cytoplasmic membrane. We have a tendency to more showed that facilitating RGD-PEG-GNR uptake in cancer cells significantly enhanced their radiosensitivity and therefore increased DNA injury. In vivo distribution revealed vital accumulation of the RGD-PEG-GNRs in tumor tissues as compared to other major organs. Such tumor lesion accumulation peaked at twelve h followed by a decline over time. In the RESs, the liver is the most important organ for RGD-PEG-GNR accumulation followed by the lung and then the spleen. Our results inspired additional development of RGD-PEG-GNR-augmented megavoltage radiation therapy and potential integration with chemotherapy targeting molecular mechanisms of DNA damage repair.
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