Multi-scale approach for simulating time-delay biochemical reaction systems


This study presents a multi-scale approach for simulating time-delay biochemical reaction systems when there are wide ranges of molecular numbers. The authors construct a brand new economical approach based on partitioning into slow and fast subsets in conjunction with predictor-corrector methods. This multi-scale approach is shown to be abundant additional economical than existing ways like the delay stochastic simulation algorithm and the changed next reaction technique. Numerical testing on several important problems in systems biology confirms the accuracy and computational potency of this approach.

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