PROJECT TITLE :
Biosynthesis of tellurium nanoparticles by Lactobacillus plantarum and the effect of nanoparticle-enriched probiotics on the lipid profiles of mice
Hypercholesterolemia is a crucial risk factor contributing to atherosclerosis and coronary heart disease. Lactic acid bacteria have attracted abundant attention regarding their promising impact on serum cholesterol levels. Tellurium (Te) is a rare element that has conjointly gained considerable interest for its biological effects. There have been some recent in vivo reports on the reduction result of Te on cholesterol content. During this study, Lactobacillus plantarum PTCC 1058 was employed for the intracellular biosynthesis of Te NPs. The UV-visible spectrum of purified NPs showed a peak at 214 nm related to the surface plasmon resonance of the Te NPs. Transmission electron microscopy showed that spherical nanoparticles without aggregation had the typical size of forty five.7 nm as determined by the laser scattering technique. The energy dispersive X-ray pattern confirmed the presence of Te atoms while not any impurities. A important reduction was observed in cluster which received L. plantarum with or without Te NPs throughout propylthiouracil and cholesterol diet in compare with the management cluster which received just propylthiouracil and cholesterol. The levels of triglycerides additionally remarkably decrease (p <; zero.05) in mice given L. plantarum with intracellular Te NPs.
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