PROJECT TITLE :

Development of a Body Shield for Small Animal PET System to Reduce Random and Scatter Coincidences

ABSTRACT:

For little animal positron emission tomography (PET) analysis using high radioactivity, like dynamic studies, the ensuing high random coincidence rate of the system degrades image quality. The random coincidence rate is increased not only by the gamma photons from within the axial-field-of-view (axial-FOV) of the PET system but additionally by those from outside the axial-FOV. For brain imaging in small animal studies, important interference is observed from gamma photons emitted from the body. Single gamma photons from the body enter the axial-FOV and increase the random and scatter coincidences. Shielding against the gamma photons from outside the axial-FOV would improve the image quality. For this purpose, we have a tendency to developed a body defend for a small animal PET system, the microPET Primate 4-ring system, and evaluated its performance. The body defend is made of nine-mm-thick lead and it surrounds most of a rat's body. We have a tendency to evaluated the effectiveness of the body shield using a head phantom and a body phantom with a radioactivity concentration ratio of one:a pair of and a most total activity of roughly 250 MBq. The random coincidence rate was dramatically decreased to ~1/10, and therefore the noise equivalent count rate (NECR) was increased ~vi times with an activity of seven MBq in the pinnacle phantom. The true count rate was increased to ~35percent due to the decrease in system deadtime. The common scatter fraction was decreased to one/a pair of.5 with the body shield. Count rate measurements of rat were additionally conducted with an injection activity of approximately twenty five MBq of [C-11]N,N-dimethyl-a pair of-(a pair of-amino-4-cyanophenylthio) benzylamine ([C-eleven]DASB) and approximately seventy and 310 MBq of 2-deoxy-a pair of-(F-eighteen)fluoro-D-glucose ([F-18]FDG). Using the body defend, [F-18]FDG pictures of rats were improved by increasing the amount of radioactivity injected. The body defend designed for tiny animal PET systems may be a promising tool for improving image quality and quantitation accuracy in tiny animal molecular imaging research.


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