Label-Free CMOS Bio Sensor With On-Chip Noise Reduction Scheme for Real-Time Quantitative Monitoring of Biomolecules


We present a label-free CMOS field-effect transistor sensing array to detect the surface potential change affected by the negative charge in DNA molecules for real-time monitoring and quantification. The proposed CMOS bio sensor includes a new sensing pixel architecture implemented with correlated double sampling for reducing offset fixed pattern noise and $1/{rm f}$ noise of the sensing devices. We incorporated non-surface binding detection which allows real-time continuous monitoring of DNA concentrations without immobilizing them on the sensing surface. Various concentrations of 19-bp oligonucleotides solution can be discriminated using the prototype device fabricated in 1-$mu{rm m}$ double-poly double-metal standard CMOS process. The detection limit was measured as 1.1 ${rm ng}/mu {rm l}$ with a dynamic range of 40 dB and the transient response time was measured less than 20 seconds.

Did you like this research project?

To get this research project Guidelines, Training and Code... Click Here

PROJECT TITLE :A Graphene-Based THz Ring Resonator for Label-Free SensingABSTRACT:During this paper, we have a tendency to report on a unique resonant THz sensor for label-free analysis. The structure consists of a silicon nitride
PROJECT TITLE : Sleep Scheduling for Geographic Routing in Duty-Cycled Mobile Sensor Network - 2014 ABSTRACT: Recently, the research focus on geographic routing, a promising routing scheme in wireless sensor networks (WSNs),
PROJECT TITLE : Secure and Efficient Data Transmission for Cluster-Based Wireless Sensor Networks - 2014 ABSTRACT: Secure data transmission is a critical issue for wireless sensor networks (WSNs). Clustering is an effective
PROJECT TITLE : R3E Reliable Reactive Routing Enhancement for Wireless Sensor Networks - 2014 ABSTRACT: Providing reliable and efficient communication under fading channels is one of the major technical challenges in wireless
PROJECT TITLE : PSR A Lightweight Proactive Source Routing Protocol For Mobile Ad Hoc Networks - 2014 ABSTRACT: Opportunistic data forwarding has drawn much attention in the research community of multihop wireless networking,

Ready to Complete Your Academic MTech Project Work In Affordable Price ?

Project Enquiry